Krok 1 – 2013 Base(Path-Physiology)

Patient with hypochromic anemia has splitting hair and loss of hair, increased nail brittling and taste alteration. What is the mechanism of the development of these symptoms?

A 27- year-old woman has dropped penicillin containing eye drops. In few minutes there appeared feeling of itching, burning of the skin, lips and eyelids edema, whistling cough, decreasing of BP. What antibodies take part in the development of this allergic reaction?

A patient underwent a surgery for excision of a cyst on pancreas. After this he developed haemorrhagic syndrome with apparent disorder of blood coagulation. Development of this complication can be explained by:

A 43-year-old patient has thrombopenia, reduction of fibrinogen, products of degradation of fibrin presented in the blood, petechial haemorrhage along with septic shock. What is the most likely cause of the changes?

Pyruvate concentration in the patient’s urine has increased 10 times from normal amount. What vitamin deficiency can be the reason of this change:

Person has stable HR, not more than 40 bpm. What is the pacemaker of the heart rhythm in this person?

A 32-year-old patient was admitted to the hospital with gross bloodloss due to auto accident trauma. Ps – 110 Bpm, RR- 22 pm, BP- 100/60mm Hg. What changes in the blood will occur in an hour after the bloodloss?

A 70-year-old patient suffers from atherosclerosis complicated by the lower limb thrombosis that has caused gangrene on his left toes. What is the most likely cause of the thrombosis origin?

ECG of a 44-year-old patient shows signs of hypertrophy of both ventricles and the right atrium. The patient was diagnosed with the tricuspid valve insufficiency. What pathogenetic variant of cardiac dysfunction is usually observed in case of such insufficiency?

Shock and signs of acute renal failure (ARF) developed in the patient due to permanent injury. What is the leading cause of development of ARF in the case?

Substitution of the glutamic acid on valine was revealed while examining initial molecular structure. For what inherited pathology is this typical?

Inflammation is characterised by increasing penetration of vessels of microcirculation stream, increasing of their fluid dynamic blood pressure. Increasing of the osmotic concentration and dispersity of protein structures present in the intercellular fluid. What kind of edema will appear in this case?

Disorder of the airways passage in small and middle bronchi was revealed in the patient. What disorder of the acid-base equilibrium can be detected in the blood?

A 62-year-old patient was admitted to the neurological department due to cerebral haemorrage. Condition is grave. There is observed progression of deepness and frequency of breath that turnes into reduction to apnoea,and the cycle repeates. What respiration type has developed in the patient?

In a 45-year-old patient on ECG it was revealed: sinus rhythm, the number of auricular complexesexceeds number of ventricular complexes; progressing extension of the P-Q interval from complex to complex; fallout of some ventricular complexes; Р waves and QRST complexes are without changes. Name the type of heart rhythm disfunction

A 57-year-old patient was admitted to the gastroenterological department with suspicion on Zollinger-Ellison syndrom because of rapid increase of gastrin level in the blood serum. What disorder of the secretory function of the stomach is the most likely?

A healthy woman has three sons affected by color blindness who were born after her two marriages. Children both of her husbands are healthy. What is the most possible pattern of inheritance of this disease?

Upper neck node of sympathetic trunk was removed from the rabbit on experiment. Reddening and increased temperature of the skin of head is observed. What form of peripheral circulation of the blood developed in the rabbit?

A couple came for medical genetic counseling. The man has hemophilia, the woman is healthy and there were no cases of hemophilia in her family. What is the risk of having a sick child in this family?

Oval and round organelles with double wall are seen at the electron micrograph. The outer membrane is smooth, the inner membrane folded into cristae contain enzyme ATPase synthetase. These are:

A tissue sample of benign tumor was studied under the electron microscope. A lot of small (15-20 nm) spherical bodies, consisting of 2 unequal subunits were detected. These are:

A woman who was sick with rubella during the pregnancy gave birth to a deaf child with hare lip and cleft palate. This congenital defect is an example of:

A woman who was infected with toxoplasmosis during the pregnancy has a child with multiple congenital defects.This is a result of:

A patient with tissue trauma was taken a blood sample for the determination of blood clotting parameters. Specify the right sequence of extrinsic pathway activation

A patient with the symptoms of acute alcoholic poisoning was brought to the hospital. What carbohydrates metabolism changes are typical for this condition?

In result of the damage of one of the Atomic Power Plant reactor the run-out of radioelements happened. People in the increased radiation zone were radiated with approximately 250-300 r. They were immediately hospitalized. What changes in the blood count would be typical?

Dystrophic changes of the heart muscle are accompanied with cardiac cavity enlargement, decrease of the strength of heart contraction, increased amount of blood, which remains in the heart during systolic phase, overfilled veins. For what state of heart is it characteristic?

Transmural myocardial infarction in the patient was complicated with progressive acute left ventricle insufficiency. What is the most typical for this state?

Arterial hypertention is caused by the stenosis of the renal arteries in the patient. Activation of what system is the main link in the pathogenesys of this form of hypertension?

A 12-year-old boy often suffers from virus and bacterial infections and eczematous skin lesions. Enlargement of T-lymphocytes and IgM with normal IgA and IgG was revealed on examination. What type of immune system pathology is presented in the patient?

Patient with diabetes didn’t get insulin injection in time that caused hyperglycemic coma (glucose in the blood 50 mmol/L). What mechanism is prevalent in the development of the coma?

Necrosis focus appeared in the area of hyperemia and skin edema in few hours after burn. What mechanism strengthens destructive events in the inflammation area?

Processes of repolarisation are disturbed in ventricular myocardium in examined person. It will cause amplitude abnormalities of configuration and duration of the wave:

On simulation of inflammation of the lower extremity the animal experienced raise of the temperature, increase of amount of antibodies and leucocytes in the blood. What substances caused this general reaction of the organism on inflammation?

A 68-year-old woman cant move by the upper and lower right extremities due to insult. Muscle tone of these extremities and reflexes are increased. There are pathological reflexes. What form of the paralysis is it?

After a serious psycho-emotional stress a 45-year-old patient suddenly felt constricting heart pain irradiating to the left arm, neck and left scapula. His face turned pale, the cold sweat stood out on it. The pain attack was stopped with nitroglycerine. What process has developed in this patient?

Periodic renal colics attackes are observed in the woman with primary hyperparathyroidizm. Ultrasonic examination revealed small stones in the kidneys. What is the cause of the formation of the stones?

While having the dinner the child choked and aspirated the food. Heavy cough has started, skin and mucosa are cyanotic, rapid pulse, rear breathing, expiration is prolonged. What disorder of the external breathing developed in the child?

Chronic glomerulonephritis was diagnosed in a 34-year-old patient 3 years ago. Edema has developed in the last 6 montes. What caused it?

While playing volleyball a sportsman made a jump and landed on the outside edge of his foot. He felt acute pain in the talocrural joint, active movements are limited, passive movements are unlimited but painful. A bit later there appeared a swelling in the area of external ankle, the skin became red and warm. What type of peripheral circulation disturbance is the case?

Having helped to eliminate consequences of a failure at a nuclear power plant, a worker got an irradiation doze of 500 roentgen. He complains of headache, nausea, dizziness. What changes in leukocytes quantity can be expected 10 hours after irradiation?

A 12 y.o. boy who suffers from bronchial asthma has an acute attack of asthma: evident expiratory dyspnea, skin pallor. What type of alveolar ventilation disturbance is it?

A 46-year-old patient suffering from the diffuse toxic goiter underwent resection of the thyroid gland. After the surgery the patient presents with appetite loss, dyspepsia, increased neuromuscular excitement. The body weight remained unchanged. Body temperature is normal. Which of the following has caused such a condition in this patient?

To prevent the transplant rejection after organ transplantation it is required to administer hormonotherapy for the purpose of immunosuppression. What hormones are used for this purpose?

A patient caught a cold after which there appeared facial expression disorder. He cannot close his eyes, raise his eyebrows, bare his teeth. What nerve is damaged?

A patient with a history of chronic glomerulonephritis presents with azotemia, oliguria, hypo- and isosthenuria, proteinuria. What is the leading factor in the pathogenesis of these symptoms development under chronic renal failure?

After an attack of bronchial asthma a patient had his peripheral blood tested. What changes can be expected?

After the traumatic tooth extraction a patient is complaining of acute, dull, poorly-localized pain in gingiva, body temperature rise up to 37,5°C. The patient has been diagnosed with alveolitis. Specify the kind of pain in this patient:

A 50 year old patient suffers from essential hypertension. After a physical stress he experienced muscle weakness, breathlessness, cyanosis of lips, skin and face. Respiration was accompanied by distinctly heard bubbling rales. What mechanism underlies the development of this syndrome?

A patient with obliterating endarteritis underwent ganglionic sympathectomy. What type of arterial hyperaemia should have developed as a result of the surgery?

A group of mountain climbers went through the blood analysis at the height of 3000 m. It revealed decrease of HCO₃ to 15 micromole/l (standard is 22-26 micromole/l). What is the mechanism of HCO₃ decrease?

ECG of a patient shows such alterations: P-wave is normal, P-Q-interval is short, ventricular QRST complex is wide, R-wave is double-peak or two-phase. What form of arrhythmia is it?

A patient who suffers from pneumonia has high body temperature. What biologically active substance plays the leading part in origin of this phenomenon?

A 34 year old woman was diagnosed with hereditary microspherocytic hemolytic anemia (Minkowsky-Shauffard disease). What mechanism caused haemolysis of erythrocytes?

From the group of children who were eating sweet sappy watermelon two kids developed the signs of poisoning: rapid weakness, dizziness, headache, vomiting, edema, tachycardia, cyanosis of mouth, ears, tips of the fingers cyanosis. High concentration of nitrates was detected. What is the leading mechanism of the pathogenesis of the poisoning in the two children?

2 years ago a patient underwent resection of pyloric part of stomach. He complains of weakness, periodical dark shadows beneath his eyes, dyspnea. In blood: Hb – 70 g/l, erythrocytes – 3,0×10¹²l, colour index – 0,7. What changes of erythrocytes in blood smears are the most typical for this condition?

During a prophylactic medical examination a 7-year-old boy was diagnosed with daltonism. His parents are healthy and have normal colour vision, but his grandfather on his mother’s side has the same abnormality. What is the type of the abnormality inheritance?

A 27 y.o. patient put eye drops that contain penicillin. After a few minutes she felt itching and burning of her body, there appeared lip and eye-lid edemata; arterial pressure began to drop. What immunoglobulins took part in the development of this allergic reaction?

Inflammation of a patients eye was accompanied by accumulation of turbid liquid with high protein at the bottom of anterior chamber that was called hypopyon. What process underlies the changes under observation?

A 48 y.o. patient was admitted to the hospital with complaints about weakness, irritability, sleep disturbance. Objectively: skin and scleras are yellow. In blood: conjugated bilirubin, cholalemia. Feces are acholic. Urine is of dark colour (bilirubin). What jaundice is it?

A patient who suffers from severe disorder of water-salt metabolism experienced cardiac arrest in diastole. What is the most probable mechanism of cardiac arrest in diastole?

A patient who suffers from heart failure has enlarged liver, edemata of lower extremities, ascites. What is the leading mechanism in the development of this edema?

Two weeks after lacunar tonsillitis a 20-year-old man started complaining about general weakness, lower eyelid edemata. After examination the patient was diagnosed with acute glomerulonephritis. What are the most likely pathological changes in the urine formula?

A 32 y.o. man is tall, he has gynecomastia, adult woman pattern of hair distribution, high voice, mental deficiency, sterility. Provisional diagnosis is Klinefelter’s syndrome. In order to specify diagnosis it is necessary to analyze:

Examination of a miner revealed pulmonary fibrosis accompanied by disturbance of alveolar ventilation. What is the main mechanism of this disturbance?

After transfusion of 200 ml of blood a patient presented with body temperature rise up to 37,9 ^oC Which of the following substances is the most likely cause of temperature rise?

A 49 y.o. woman consulted a doctor about heightened fatigue and dyspnea during physical activity. ECG: heart rate is 50/min, PQ is extended, QRS is unchanged, P wave quantity exceeds quantity of QRS complexes. What type of arrhythmia does the patient have?

A woman has been applying a new cosmetic preparation for a week that resulted in eye-lid inflammation accompanied by hyperemia, infiltration and painfulness. What type of allergic reaction was developed?

A patient is followed up in an endocrinological dispensary on account of hyperthyreosis. Weight loss, tachycardia, finger tremor are accompanied by hypoxia symptoms – headache, fatigue, eye flicker. What mechanism of thyroid hormones action underlies the development of hypoxia?

A 56 y.o. patient has been suffering from thyreotoxicosis for a long time. What type of hypoxia can be developed?

An animal with aortic valve insufficiency got hypertrophy of its left heart ventricle. Some of its parts have local contractures. What substance accumulated in the myocardiocytes caused these contractures?

A girl is diagnosed with adrenogenital syndrome (pseudohermaphroditism). This pathology was caused by hypersecretion of the following adrenal hormone:

A patient has extrasystole. ECG shows no P wave, QRS complex is deformed, there is a full compensatory pause. What extrasystoles are these?

After a serious psychoemotional stress a 48 year old patient suddenly developed acute heart ache irradiating to the left arm. Nitroglycerine relieved pain after 10 minutes. What is the leading pathogenetic mechanism of this process development?

A 12-year-old teenager has significantly put off weight within 3 months; glucose concentration rose up to 50 millimole/l. He fell into a coma. What is the main mechanism of its development?

As a result of increased permeability of the erythrocyte membrane in a patient with microspherocytic anaemia (Minkowsky-Shauffard disease) cells receive sodium ions and water. Erythrocytes take form of spherocytes and can be easily broken down. What is the leading mechanism of erythrocyte damage in this case?

A 56 year old patient suffering from cardiac insufficiency has edema of feet and shins, edematous skin is pale and cold. What is the leading mechanism of edema pathogenesis?

A disaster fighter at a nuclear power plant developed hemorrhagic syndrome on the background of acute radiation disease. What is the most important factor of syndrome pathogenesis?

Prophylactic medical examination of a 36 year old driver revealed that his AP was 150/90 mm Hg. At the end of working day he usually hears ear noise, feels slight indisposition that passes after some rest. He was diagnosed with essential hypertension. What is the leading pathogenetic mechanism in this case?

Blood analysis of a patient with jaundice reveals conjugated bilirubinemia, increased concentration of bile acids. There is no stercobilinogen in urine. What type of jaundice is it?

Violation of safety rules resulted in calomel intoxication. Two days later the daily diuresis was 620 ml. A patient complained of headache, vomiting, convulsions, dyspnea, moist rales in lungs. What pathology is it?

A newborn child with pylorostenosis has often repeating vomiting accompanied by apathy, weakness, hypertonicity, sometimes convulsions. What disorder form of acid-base balance is it?

24 hours after appendectomy patients blood analysis showed neutrophilic leukocytosis with regenerative shift. What is the most probable mechanism of leukocytosis development?

A 59 year old patient is a plant manager. After the tax inspection of his plant he felt intense pain behind his breastbone irradiating to his left arm. 15 minutes later his condition came to normal. Which of the possible mechanisms of stenocardia development is the leading in this case?

Arterial pressure of a surgeon who performed a long operation raised up to 140/110 mm Hg. What changes of humoral regulation could have caused the rise of arterial pressure in this case?

A 50-year-old patient complains of thirst, drinking of a lot of water, marked polyuria. Blood glucose is 4,8 mmol/L, urine glucose and acetone bodies are absent, urine is colorless, specific gravity is 1,002 – 1,004. What is the cause of polyuria?

A patient was ill with burn disease that was complicated by DIC syndrome. What stage of DIC syndrome can be suspected if it is known that the patients blood coagulates in less than 3 minutes?

A 55 y.o. woman consulted a doctor about having continuous cyclic uterine hemorrhages for a year, weakness, dizziness. Examination revealed skin pallor. Hemogram: Hb- 70 g/l, erythrocytes – 3,2×10¹²/l, color index – 0,6, leukocytes – 6,0×10⁹/l, reticulocytes – 1%; erythrocyte hypochromia. What anemia is it?

A 56 year old patient came to a hospital with complaints about general weakness, tongue pain and burning, sensation of limb numbness. In the past he underwent resection of fore stomach. In blood: Hb- 80 g/l; erythrocytes – 2,01×10¹²/l; colour index – 1,2, leukocytes – 3,5×10⁹/l. What type anemia is it?

The patient with acute miocardial infarction was given intravenously different solutions during 8 hours with medical dropper 1500 ml and oxygen intranasally. He died because of pulmonary edema. What caused the pulmonary edema?

A 25 year old Palestinian woman complains of weakness, dizziness, dyspnea. In anamnesis: periodically exacerbating anemia. In blood: Hb – 60 g/l, erythrocytes – 2,5×10¹²/l, reticulocytes – 35o/oo, anisocytosis and poikilocytosis of erythrocytes, a lot of target cells and polychromatophils. What type of anemia is it?

A 23 y.o. patient complains of weakness, temperature rise up to 38-40°C. Objectively: liver and spleen are enlarged. Hemogram: Hb- 100 g/l, erythrocytes – 2,9×10¹²/l, leukocytes – 4,4×10⁹/l, thrombocytes – 48×10⁹/l, segmentonuclear neutrophils – 17%, lymphocytes – 15%, blast cells – 68%. All cytochemical reactions are negative. Make a hematological conclusion:

Inflammatory processes cause synthesis of protein of acute phase in an organism. What substances stumulate their synthesis?

A chemical burn caused esophagus stenosis. Difficulty of ingestion led to the abrupt loss of weight. In blood: 3,0×10¹²/l, Hb – 106 g/l, crude protein – 57 g/l. What type of starvation is it?

A 42 year old woman with neuralgia of trifacial nerve complains about periodical reddening of the right part of her face and neck, sense of warmth gush, increased skin sensitivity. These effects can be explained by the following type of arterial hyperemia:

A patient who suffers from acute myocarditis has clinical signs of cardiogenic shock. What of the under-mentioned pathogenetic mechanisms plays the main part in shock development?

On the 6^th day of treatment a patient with acute renal insufficiency developed polyuria. Diuresis intensification at the beginning of polyuria stage of acute renal insufficiency is caused by:

A 30 year old woman has face edemata. Examination revealed proteinuria (5,87 g/l), hypoproteinemia, dysproteinemia, hyperlipidemia. What condition is the set of these symptoms typical for?

A patient with nephrotic syndrome has massive edemata of his face and limbs. What is the leading pathogenetic mechanism of edemata development?

A patient staying in the pulmonological department was diagnosed with pulmonary emphysema accompanied by reduced elasticity of pulmonary tissue. What type of respiration is observed?

An unconscious young man with signs of morphine poisoning entered admission office. His respiration is shallow and infrequent which is caused by inhibition of respiratory centre. What type of respiratory failure is it?

A patient has been diagnosed with acute glomerulonephritis that developed after he had had streptococcal infection. It is most likely that the affection of basal glomerular membrane is caused by an allergic reaction of the following type:

Examination of patients with periodontitis revealed the interdependence between the rate of affection of periodontal tissues and the amount of lysozymes in saliva and gingival liquid. These results can be obtained during studying the following protection system of an organism:

A 62 year old patient who previously worked as stoker was admitted to a hospital with complaints about general weakness, abrupt weight loss, hoarse voice, dyspnea, dry cough. Laryngoscopy revealed a tumour in the pharynx that invaded vocal cords and epiglottis. What is the most probable cause of tumour development?

Tuberculine was injected intraperitoneally to the animal sensibilized with tuberculine. Venous hyperemia and peritonial edema were detected on the laparotomy in 24 hours. Increased amount of lymphocytes and monocytes were in the smear-print from the peritonium. What pathological process is in the animal?

Daltonism was diagnosed in a 7-year-old boy while prophylactic medical examination. Parents are healthy, color vision is normal. Grandfather from the mothers side has the same disorder. What is the type of inheriting of this anomaly?

A married couple came to the genetic counseling. The husband suffers from the insulin-dependant diabetes, the wife is healthy. What is the probability that this couple will have an insulin-dependant child?

A patient who had been working hard under conditions of elevated temperature of the environment, has now a changed quantity of blood plasma proteins. What phenomenon is the case?

An infant has pylorospasm, weakness, hypodynamia, convulsions as a result of frequent vomiting. What kind of acid-base disbalance is it?

An experimental rat with extremity paralysis has no tendon and cutaneous reflexes, muscle tone is decreased, but muscles of the affected extremity maintain their ability to react with excitation to the direct action of continious current. What type of paralysis is it?

A 28 year old man had a gunshot wound of shin that resulted in an ulcer from the side of the injury. What is the main factor of neurodystrophy pathogenesis in this case?

Blood test of a patient suffering from atrophic gastritis gave the following results: RBCs – 2,0×10¹²/l, Hb- 87 g/l, colour index – 1,3, WBCs – 4,0×10⁹/l, thrombocytes – 180×10⁹/l. Anaemia migh have been caused by the following substance deficiency:

A 45 year old patient was admitted to the cardiological department. ECG data: negative P wave overlaps QRS complex, diastolic interval is prolonged after extrasystole. What type of extrasystole is it?

A rabbits nerve that innervates the right ear was cut and its right superior cervical ganglion was removed. Immediately after operation the temperature of ear skin was measured. It was revealed that the temperature of the rabbits ear skin on the side of denervation was by 1,5⁰C higher than on the opposite intact side. What of the following is the most probable explanation of the above-mentioned effects?

Two hours after an exam a student had a blood count done and it was revealed that he had leukocytosis without significant leukogram modifications. What is the most probable mechanism of leukocytosis development?

A patient presents with icteritiousness of skin, scleras and mucous membranes. Blood plasma the total bilirubin is increased, stercobilin is increased in feces, urobilin is increased in urine. What type of jaundice is it?

Hepatitis has led to the development of hepatic failure. Mechanism of edemata formation is activated by the impairment of the following liver function:

As a result of a road accident a 26-year-old man is in the torpid phase of shock. Blood count: leukocytes – 3,2×10⁹/l. What is the leading mechanism of leukopenia development?

As a result of a trauma a patient has developed traumatic shock that led to the following disorders: AP is 140/90 mm Hg, Ps is 120 bpm. The patient is fussy, talkative, pale. Such state relates to the following shock phase:

Examination of a patient admitted to the surgical department with symptoms of acute appendicitis revealed the following changes in the white blood cells: the total count of leukocytes is 16×10⁹/l. Leukocyte formula: basophils – 0, eosinophils – 2%, juvenile forms – 2%, stabnuclear – 8%, segmentonuclear – 59%, lymphocytes – 25%, monocytes- 4%. The described changes can be classified as:

A patient being treated for viral hepatitis type B got symptoms of hepatic insufficiency. What blood changes indicative of protein metabolism disorder will be observed in this case?

A patient was stung by a bee. Examination revealed that his left hand was hot, pink, edematic, there was a big red blister on the site of sting. What is the leading mechanism of edema development?

A patient consulted a dentist about itching and burning in the oral cavity; high temperature. The patient was diagnosed with trichomonal gingivostomatitis. What drug should be chosen for his treatment?

A patient suffering from pheochromocytoma complains of thirst, dry mouth, hunger. Blood test for sugar revealed hyperglycemia. What type of hyperglycemia is it?

A patient suffering from stenocardia was taking nitroglycerine which caused restoration of blood supply of myocardium and relieved pain in the cardiac area. What intracellular mechanism provides restoration of energy supply of insulted cells?

A couple had a child with Downs disease. Mother is 42 years old. This disease is most probably caused by the following impairment of prenatal development:

There are several groups of molecular mechanisms playing important part in pathogenesis of insult to cells which contributes to the pathology development. What processes are stimulated by proteinic damage mechanisms?

A child was born with cleft palate. Examination revealed aorta defects and reduced number of T-lymphocytes in blood. What immunodeficient syndrome is it?

Examination of a child who frequently suffers from infectious diseases revealed that IgG concentration in blood serum was 10 times less than normal, IgA and IgM concentration was also significantly reduced. Analysis showed also lack of B-lymphocytes and plasmocytes. What disease are these symptoms typical for?

A driver who got a trauma in a road accident and is shocked has reduction of daily urinary output down to 300 ml. What is the main pathogenetic factor of such diuresis change?

Examination of a 42 year old patient revealed a tumour of adenohypophysis. Objectively: the patients weight is 117 kg, he has moon-like hyperemic face, red-blue striae of skin distension on his belly. Osteoporosis and muscle dystrophy are present. AP is 210/140 mm Hg. What is the most probable diagnosis?

Examination of a 12 year old boy with developmental lag revealed achondroplasia: disproportional constitution with evident shortening of upper and lower limbs as a result of growth disorder of epiphyseal cartilages of long tubal bones. This disease is:

A patient was diagnosed with autoimmune hemolitic cytotoxic anemia. What substances are antigens in II type allergic reactions?

A patient suffers from the haemorrhagic syndrome that shows itself in frequent nasal bleedings, posttraumatic and spontaneous intracutaneous and intra-articular haemorrhages. After a laboratory study a patient was diagnosed with the type B haemophilia. This disease is provoked by the deficit of the following factor of blood coagulation:

A 58-year-old patient suffers from the cerebral atherosclerosis. Examination revealed hyperlipoidemia. What class of lipoproteins will most probably show increase in concentration in this patient’s blood serum?

A 67 year old patient complains of periodic heart ache, dyspnea during light physical activities. ECG reveals extraordinary contractions of heart ventricles. Such arrhythmia is called:

In course of a preventive examination of a miner a doctor revealed changes of cardiovascular fitness which was indicative of cardiac insufficiency at the compensation stage. What is the main proof of cardiac compensation?

A 47 year old man with myocardium infarction was admitted to the cardiological department. What changes of cellular composition of peripheral blood are induced by necrotic changes in the myocardium?

An infectious disease unit admitted a patient with signs of jaundice caused by hepatitis virus. Select an indicator that is specific only for parenchymatous jaundice:

A patient with skin mycosis has disorder of cellular immunity. The most typical characteristic of it is reduction of the following index:

A patient with massive burns developed acute renal insufficiency characterized by a significant and rapid deceleration of glomerular filtration. What is the mechanism of its development?

A child is pale, pastose, muscular tissue is bad developed, lymph nodes are enlarged. He often suffers from angina and pharyngitis, blood has signs of lymphocytosis. The child is also predisposed to autoallergic diseases. What type of diathesis can be presumed in this case?

A 26 year old pregnant woman is treated at an in-patient hospital. After a continuous attack of vomiting it was found reduced volume of her circulating blood. What kind of changes in general blood volume will appear?

Parents of a 3 year old child have been giving him antibiotics with purpose of preventing enteric infections for a long time. A month later the child’s condition changed for the worse. Blood examination revealed apparent leukopenia and granulocytopenia. What is the most probable mechanism of blood changes?

A patient ill with enteritis accompanied by massive diarrhea has low water rate in the extracellular space, high water rate inside the cells and low blood osmolarity. What is such disturbance of water-electrolytic metabolism called?

A patient with obliterating atherosclerosis underwent sympathectomy of femoral artery in the region of femoral trigone. What type of arterial hyperemia was induced by the operation?

A 15 year old girl has pale skin, glossitis, gingivitis. Blood count: erythrocytes – 3,3×10¹²/l, hemoglobin – 70 g/l, colour index – 0,5. Examination of blood smear revealed hypochromia, microcytosis, poikilocytosis. What type of anemia is it?

A 70 year old man is ill with vascular atherosclerosis of lower extremities and coronary heart disease. Examination revealed disturbance of lipidic blood composition. The main factor of atherosclerosis pathogenesis is the excess of the following lipoproteins:

A patient ill with essential arterial hypertension had a hypertensic crisis that resulted in an attack of cardiac asthma. What is the leading mechanism of cardiac insufficiency in this case?

A 5 year old child is ill with measles. Blood analysis revealed increase of total number of leukocytes up to 13×10⁹/l. Leukogram: basophils – 0, eosinophils – 1, myelocytes – 0, juvenile neutrophils – 0, band neutrophils – 2, segmented neutrophils – 41, lymphocytes – 28, monocytes – 28. Name this phenomenon:

Rats being under stress have muscular hypertonia and high arterial pressure, high glucose concentration in blood and intensified secretion of corticotropin and corticosteroids. In what stress phase are these animals?

After taking poor-quality food a patient developed repeated episodes of diarrhea. On the next day he presented with decreased arterial pressure, tachycardia, extrasystole. Blood pH is 7,18. These abnormalities were caused by the development of:

A patient has been diagnosed with influenza. His condition became drastically worse after taking antipyretic drugs. His consciousness is confused, AP is 80/50 mm Hg, Ps is 140/m, body temperature droped down to 35,8°C. What complication developed in this patient?

A patient was admitted to the infectious department. His symptoms: dry skin, decreased skin turgor, rice-water stool. The patient was diagnosed with cholera. What disorder of water-electrolytic balance is most often observed in this disease?

A 45 year old woman is ill with breast cancer. Her left arm has symptoms of lymphatic system insufficiency – limb edema, lymph node enlargement. What form of lymphatic circulation insufficiency is it?

A 25 year old man has spent a long time in the sun under high air humidity. As a result of it his body temperature rose up to 39 ^oC What pathological process is it?

A 26 year old man is in the torpid shock phase as a result of a car accident. In blood: 3,2×10⁹/l. What is the leading mechanism of leukopenia development?